In thinking about these questions I have been stimulated by criticisms of the prevailing scientific world picture... by the defenders of intelligent design. Even though writers like Michael Behe and Stephen C. Meyer are motivated at least in part by their religious beliefs, the empirical arguments they offer against the likelihood that the origin of life and its evolutionary history can be fully explained by physics and chemistry are of great interest in themselves. Another skeptic, David Berlinski, has brought out these problems vividly without reference to the design inference. Even if one is not drawn to the alternative of an explanation by the actions of a designer, the problems that these iconoclasts pose for the orthodox scientific consensus should be taken seriously. They do not deserve the scorn with which they are commonly met. It is manifestly unfair.